Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061808 | 0.89 | HPGDS (0.49) | HPGDSTSHRMAPK1LMNAHTT | |
| SCHEMBL17967327 | 0.84 | HPGDS (0.64) | HPGDSPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL30012192 | 0.80 | CSF1R (0.54) | HPGDSTSHRMEN1KMT2AKDM4E | |
| SCHEMBL27765442 | 0.79 | HPGDS (0.74) | HPGDSPARP10CHEK2 | |
| SCHEMBL20799516 | 0.78 | HPGDS (0.59) | HPGDSPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL19020876 | 0.77 | HPGDS (0.46) | HPGDSTSHRPDGFRBPDGFRA | |
| SCHEMBL3873425 | 0.77 | HPGDS (0.58) | HPGDSPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL19021397 | 0.77 | MGAM (0.45) | HPGDSTSHRHTTPDGFRBPDGFRA | |
| SCHEMBL18988204 | 0.75 | EGLN1 (0.53) | HPGDSTSHRMAPK1LMNAHTT | |
| SCHEMBL28448861 | 0.75 | PDGFRB (0.51) | LMNAPDGFRBPDGFRANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718615-A1 | NOVEL QUINOLINE-CARBAXAMIDES AS JACK3 KINASE MODULATORS | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | claimed |
| WO-2005075429-A1 | NOVEL QUINOLINE-CARBAXAMIDES AS JACK3 KINASE MODULATORS | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | claimed |