Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 2/20 | 0.47 |
| ▸ | MME | P08473 | 7/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9227299 | 0.83 | TRPA1 (0.47) | KMT2ATGM2 | |
| SCHEMBL18383090 | 0.82 | HPGD (0.51) | KMT2AMEN1NPC1RAB9A | |
| SCHEMBL2600708 | 0.82 | HPGD (0.51) | KMT2AMEN1NPC1RAB9A | |
| SCHEMBL20446769 | 0.80 | LDHA (0.56) | TGM2ACACBCYP2C19 | |
| SCHEMBL22235331 | 0.78 | KMT2A (0.53) | KMT2AMEN1NPC1RAB9AMME | |
| SCHEMBL12939732 | 0.78 | MEN1 (0.57) | KMT2AMEN1NPC1RAB9AMME | |
| SCHEMBL4597385 | 0.78 | MEN1 (0.57) | KMT2AMEN1NPC1RAB9AMME | |
| SCHEMBL21129085 | 0.78 | MEN1 (0.57) | KMT2AMEN1NPC1RAB9AMME | |
| SCHEMBL13968361 | 0.78 | NPC1 (0.43) | KMT2AMEN1NPC1RAB9ATGM2 | |
| SCHEMBL8044432 | 0.78 | KMT2A (0.48) | KMT2AMEN1NPC1RAB9ATGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704139-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RAR y RETINOID RECEPTORS | Allergan, Inc. (US) | 2006-09-27 | — | — | EP | disclosed |
| EP-1701934-A2 | DISUBSTITUTED CHALCONE OXIMES HAVING RAR(Gamma)-RETINOID RECEPTOR ANTAGONIST ACTIVITY | Allergan, Inc. (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066116-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RARϜ RETINOID RECEPTORS | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |
| WO-2005066115-A2 | DISUBSTITUTED CHALCONE OXIMES HAVING RARϜ RETINOID RECEPTOR ANTAGONIST ACTIVITY | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |