Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.41 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.41 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5707695 | 0.96 | MAPT (0.64) | KMT2AMAPTMEN1CYP2D6TP53 | |
| Bromide SCHEMBL4769564 | 0.93 | KMT2A (0.72) | KMT2AMAPTMEN1CYP2D6TP53 | |
| Bromide SCHEMBL28044241 | 0.93 | KMT2A (0.72) | KMT2AMAPTMEN1CYP2D6TP53 | |
| Bromide SCHEMBL7141677 | 0.91 | KMT2A (0.75) | KMT2AMAPTMEN1CYP2D6TP53 | |
| Bromide SCHEMBL6224118 | 0.91 | KMT2A (0.75) | KMT2AMAPTMEN1CYP2D6TP53 | |
| Bromide SCHEMBL6024741 | 0.91 | KMT2A (0.75) | KMT2AMAPTMEN1CYP2D6TP53 | |
| Bromide SCHEMBL2868130 | 0.91 | KMT2A (0.75) | KMT2AMAPTMEN1CYP2D6TP53 | |
| Bromide SCHEMBL19664670 | 0.91 | KMT2A (0.75) | KMT2AMAPTMEN1CYP2D6TP53 | |
| SCHEMBL5221222 | 0.91 | KMT2A (0.74) | KMT2AMAPTMEN1CYP2D6TP53 | |
| SCHEMBL7968623 | 0.89 | KMT2A (0.78) | KMT2AMAPTMEN1CYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373250-B1 | VIOLOGEN LINKED ACRIDINE BASED MOLECULE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2006-08-30 | — | — | EP | claimed |
| EP-1373250-B1 | VIOLOGEN LINKED ACRIDINE BASED MOLECULE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2006-08-30 | — | — | EP | disclosed |
| EP-1373250-A1 | VIOLOGEN LINKED ACRIDINE BASED MOLECULE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-01-02 | — | — | EP | disclosed |
| US-6630481-B2 | Phototherapeutic and catalytic photoactivated DNA cleaving agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH OF INDIA (IN) | 2003-10-07 | — | — | US | disclosed |
| US-20030045538-A1 | Viologen linked acridine based molecule and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH OF INDIA | 2003-03-06 | — | — | US | disclosed |
| WO-2002079191-A1 | VIOLOGEN LINKED ACRIDINE BASED MOLECULE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045538-A1 | Viologen linked acridine based molecule and process for the preparation thereof | UNG, OGG1, MPG | CHRM2 4075/4885ADRA2A 4286/4885ACHE 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.