Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 4/20 | 0.45 |
| ▸ | RAD52 | P43351 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5707923 | 0.99 | MAPT (0.44) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL6692925 | 0.86 | KDM4E (0.53) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL5707910 | 0.86 | GAA (0.50) | MAPTKDM4EGAARAD52ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5707922 | 0.85 | GAA (0.49) | MAPTKDM4EGAARAD52ALDH1A1 | |
| SCHEMBL5707919 | 0.83 | MAPT (0.49) | MAPTKDM4EGAAGFERRAD52 | |
| Hydrochloric Acid SCHEMBL5707931 | 0.82 | MAPT (0.48) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL5707929 | 0.81 | MAPT (0.55) | MAPTKDM4EGAAGFERRAD52 | |
| Hydrochloric Acid SCHEMBL5707968 | 0.80 | MAPT (0.54) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL5707941 | 0.79 | KDM4E (0.53) | MAPTKDM4EGAAGFERRAD52 | |
| Hydrochloric Acid SCHEMBL5707957 | 0.78 | KDM4E (0.51) | MAPTKDM4EGAAGFERRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1462445-B1 | Paraphenyldiamine derivatives concisting of a cyclic diaza group substituted by a cationic radical and use of these derivatives for dyeing keratin fibres | OREAL (FR) | 2006-10-18 | — | — | EP | claimed |
| US-20060123565-A9 | PARA-PHENYLENEDIAMINE DERIVATIVES COMPRISING A CYCLIC DIAZA GROUP SUBSTITUTED WITH A CATIONIC RADICAL, AND USE OF THESE DERIVATIVES FOR DYEING KERATIN FIBERS | SABELLE STEPHANE | 2006-06-15 | — | — | US | claimed |
| US-20050066451-A1 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL S.A. (FR) | 2005-03-31 | — | — | US | claimed |
| EP-1462445-B1 | Paraphenyldiamine derivatives concisting of a cyclic diaza group substituted by a cationic radical and use of these derivatives for dyeing keratin fibres | OREAL (FR) | 2006-10-18 | — | — | EP | disclosed |
| US-20060123565-A9 | PARA-PHENYLENEDIAMINE DERIVATIVES COMPRISING A CYCLIC DIAZA GROUP SUBSTITUTED WITH A CATIONIC RADICAL, AND USE OF THESE DERIVATIVES FOR DYEING KERATIN FIBERS | SABELLE STEPHANE | 2006-06-15 | — | — | US | disclosed |
| US-20050066451-A1 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | L'OREAL S.A. (FR) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050066451-A1 | Para-phenylenediamine derivatives comprising a cyclic diaza group substituted with a cationic radical, and use of these derivatives for dyeing keratin fibers | KRT18, VIM, DDAH1 | MAPT 2832/4885KDM4E 1048/4885GAA 4321/4885 |
| US-20060123565-A9 | PARA-PHENYLENEDIAMINE DERIVATIVES COMPRISING A CYCLIC DIAZA GROUP SUBSTITUTED WITH A CATIONIC RADICAL, AND USE OF THESE DERIVATIVES FOR DYEING KERATIN FIBERS | KRT18, VIM, DDAH1 | MAPT 2832/4885KDM4E 1048/4885GAA 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.