Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5707909 | 0.99 | GAA (0.58) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5707952 | 0.97 | GAA (0.53) | GAARAD52KCNH2KDM4EMAPT | |
| SCHEMBL5707924 | 0.95 | GAA (0.54) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5352494 | 0.91 | GAA (0.50) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5355166 | 0.90 | GAA (0.47) | GAARAD52KCNH2KDM4EMAPT | |
| SCHEMBL6746047 | 0.89 | GAA (0.51) | GAARAD52KCNH2KDM4EMAPT | |
| SCHEMBL6744572 | 0.88 | GAA (0.48) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5707950 | 0.84 | KDM4E (0.51) | GAARAD52KCNH2KDM4EMAPT | |
| SCHEMBL5707920 | 0.82 | KDM4E (0.53) | GAARAD52KCNH2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5707943 | 0.81 | KDM4E (0.48) | GAARAD52KCNH2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1462445-B1 | Paraphenyldiamine derivatives concisting of a cyclic diaza group substituted by a cationic radical and use of these derivatives for dyeing keratin fibres | OREAL (FR) | 2006-10-18 | — | — | EP | claimed |