SCHEMBL5708166

SCHEMBL5708166

C(=C/c1ccc(-c2nc3ccccc3o2)cc1)\c1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.63
RAB9A P51151 4/20 0.63
MEN1 O00255 3/20 0.63
KMT2A Q03164 3/20 0.63
ATM Q13315 1/20 0.63
HSD17B10 Q99714 4/20 0.58
HPGD P15428 3/20 0.58
ALDH1A1 P00352 3/20 0.58
KDM4E B2RXH2 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
TP53 P04637 1/20 0.58
BCHE P06276 2/20 0.57
MMP2 P08253 1/20 0.55
MMP9 P14780 1/20 0.55
MMP8 P22894 1/20 0.55
MMP13 P45452 1/20 0.55
MAPT P10636 3/20 0.53
PTPN2 P17706 2/20 0.52
PTPN1 P18031 2/20 0.52
PTPN5 P54829 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5708171 1.00 NPC1 (0.63) NPC1RAB9AMEN1KMT2AATM
SCHEMBL231011 0.97 NPC1 (0.67) NPC1RAB9AMEN1KMT2AATM
SCHEMBL29924255 0.97 NPC1 (0.67) NPC1RAB9AMEN1KMT2AATM
SCHEMBL29924607 0.97 NPC1 (0.67) NPC1RAB9AMEN1KMT2AATM
SCHEMBL231012 0.97 NPC1 (0.67) NPC1RAB9AMEN1KMT2AATM
SCHEMBL29405696 0.97 NPC1 (0.67) NPC1RAB9AMEN1KMT2AATM
SCHEMBL19690361 0.97 NPC1 (0.67) NPC1RAB9AMEN1KMT2AATM
SCHEMBL84263 0.95 NPC1 (0.61) NPC1RAB9AMEN1KMT2AATM
SCHEMBL84264 0.95 NPC1 (0.61) NPC1RAB9AMEN1KMT2AATM
SCHEMBL29882462 0.95 NPC1 (0.61) NPC1RAB9AMEN1KMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10329481-B2 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator UNIWERSYTET JAGIELLONSKI (PL) 2019-06-25 US claimed
US-20170260447-A1 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator UNIWERSYTET JAGIELLONSKI (PL) 2017-09-14 US claimed
EP-3189523-A1 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator Uniwersytet Jagiellonski (PL) 2017-07-12 EP claimed
WO-2016036265-A1 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator Uniwersytet Jagielloński (PL) 2016-03-10 WO claimed
EP-0136259-B1 4-HETEROCYCLYL-VINYL-4'-STYRYL-BIPHENYLS CIBA-GEIGY AG (CH) 1988-06-15 EP claimed
US-4666627-A FLUORESCENT BRIGHTENERS CIBA-GEIGY CORPORATION (US) 1987-05-19 US claimed
EP-1810082-B1 PHOTOPOLYMERIZABLE COMPOSITION AGFA NV (BE) 2020-01-08 EP disclosed
EP-1810081-B1 PHOTOPOLYMERIZABLE COMPOSITION AGFA NV (BE) 2020-01-08 EP disclosed
US-10329481-B2 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator UNIWERSYTET JAGIELLONSKI (PL) 2019-06-25 US disclosed
US-10329481-B2 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator UNIWERSYTET JAGIELLONSKI (PL) 2019-06-25 US disclosed
US-20170260447-A1 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator UNIWERSYTET JAGIELLONSKI (PL) 2017-09-14 US disclosed
US-20170260447-A1 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator UNIWERSYTET JAGIELLONSKI (PL) 2017-09-14 US disclosed
EP-3189523-A1 Use of 2-(4-styrylphenyl)benzoxazole and plastic scintillator Uniwersytet Jagiellonski (PL) 2017-07-12 EP disclosed
US-6492032-B1 MIXTURE OF BENZOXAZOLYL STILBENES WITH A BIS(BENZOXAZOLYL)-NAPHTHALENE, BIS(BENZOXAZOLYL)THIOPHENE, A PYRAZOLINE AND/OR A COURMARIN; PHOTOGRAPHIC FILMS EASTMAN CHEMICAL COMPANY 2002-12-10 US disclosed
WO-2002031035-A1 MULTI-COMPONENT OPTICALLY BRIGHTENED POLYOLEFIN BLEND EASTMAN CHEMICAL COMPANY (US) 2002-04-18 WO disclosed
EP-0136259-B1 4-HETEROCYCLYL-VINYL-4'-STYRYL-BIPHENYLS CIBA-GEIGY AG (CH) 1988-06-15 EP disclosed
US-4666627-A FLUORESCENT BRIGHTENERS CIBA-GEIGY CORPORATION (US) 1987-05-19 US disclosed
EP-0136259-A1 4-Heterocyclyl-vinyl-4'-styryl-biphenyls CIBA-GEIGY AG (CH) 1985-04-03 EP disclosed
US-4129412-A 4-BENZOOXAZOL-2-YL-STILBENES HOECHST AKTIENGESELLSCHAFT (DE) 1978-12-12 US disclosed
US-3996210-A OPTICAL BRIGHTENERS SANDOZ LTD. (CH) 1976-12-07 US disclosed