Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.39 |
| ▸ | TYR | P14679 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708241 | 0.87 | MIF (0.42) | BACE1MIFAPPCHRNA7TYR | |
| SCHEMBL3930354 | 0.86 | MIF (0.55) | BACE1MIFAPPCHRNA7TYR | |
| Silver SCHEMBL11461919 | 0.74 | CHRNA7 (0.62) | BACE1CHRNA7TYRALOX5 | |
| Silver SCHEMBL11461918 | 0.74 | CHRNA7 (0.62) | BACE1CHRNA7TYRALOX5 | |
| SCHEMBL3928418 | 0.71 | MIF (0.59) | BACE1MIFAPPCHRNA7TYR | |
| SCHEMBL8388677 | 0.71 | NPSR1 (0.45) | MIF | |
| SCHEMBL7937596 | 0.69 | MIF (0.53) | BACE1MIFAPPTYRALOX5 | |
| SCHEMBL7937601 | 0.69 | MIF (0.53) | BACE1MIFAPPTYRALOX5 | |
| SCHEMBL9447849 | 0.68 | MIF (0.60) | BACE1MIFAPPCHRNA7TYR | |
| SCHEMBL26046320 | 0.68 | MIF (0.60) | BACE1MIFAPPCHRNA7TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706386-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066136-A1 | BICYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |