SCHEMBL5708359

SCHEMBL5708359

O=C1NC[C@@H](COCc2ccccc2)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 1.00
MAPT P10636 1/20 0.64
PKM P14618 1/20 0.56
USP2 O75604 1/20 0.52
ALDH1A1 P00352 1/20 0.52
HPGD P15428 1/20 0.52
HSD17B10 Q99714 1/20 0.52
MAPK1 P28482 1/20 0.50
MAOA P21397 1/20 0.47
SLC6A2 P23975 1/20 0.47
PTPN1 P18031 2/20 0.46
CDC25B P30305 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
HRH4 Q9H3N8 4/20 0.42
HRH3 Q9Y5N1 4/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1269358 1.00 LMNA (1.00) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL18844035 1.00 LMNA (1.00) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL9550079 0.80 LMNA (0.65) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL11233640 0.80 LMNA (0.65) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL1268961 0.79 LMNA (0.65) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL5409561 0.79 LMNA (0.65) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL2318768 0.79 LMNA (0.65) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL18009235 0.79 LMNA (0.64) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL1269551 0.78 PKM (0.67) LMNAMAPTPKMUSP2ALDH1A1
SCHEMBL7996555 0.78 PKM (0.67) LMNAMAPTPKMUSP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1008590-B1 Process for preparing optically active oxazolidinone derivatives TAKASAGO PERFUMERY CO LTD (JP) 2006-10-11 EP disclosed
US-6403804-B1 ALLOWING HYDRAZINE TO REACT ON OPTICALLY ACTIVE ACID ESTER HAVING HYDROXYL GROUP AT 3-POSITION TO GIVE OPTICALLY ACTIVE HYDRAZIDE HAVING HYDROXYL GROUP AT 3-POSITION, SUBJECTING OPTICALLY ACTIVE HYDRAZIDE TO CURTIUS REARRANGEMENT TAKASAGO INTERNATIONAL CORPORATION (JP) 2002-06-11 US disclosed
EP-1008590-A1 Process for preparing optically active oxazolidinone derivative Takasago International Corporation (JP) 2000-06-14 EP disclosed