Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.69 |
| ▸ | CA2 | P00918 | 5/20 | 0.69 |
| ▸ | CA4 | P22748 | 5/20 | 0.69 |
| ▸ | CA6 | P23280 | 5/20 | 0.69 |
| ▸ | MDH2 | P40926 | 1/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5708473 | 0.90 | CA1 (0.55) | CA1CA2CA4CA6MDH2 | |
| SCHEMBL5708518 | 0.84 | MAOA (0.51) | CA1CA2CA4CA6MAPKAPK2 | |
| SCHEMBL8946305 | 0.81 | CA1 (0.73) | CA1CA2CA4CA6MDH2 | |
| SCHEMBL4147028 | 0.77 | TLR9 (0.49) | MAOBMAOATRPM8CTSVCTSL | |
| SCHEMBL31053079 | 0.76 | CTSV (0.49) | MAOBMAOATRPM8CTSVCTSL | |
| SCHEMBL22628563 | 0.76 | CTSV (0.49) | MAOBMAOATRPM8CTSVCTSL | |
| SCHEMBL9527027 | 0.76 | CA1 (0.58) | CA1CA2CA4CA6MDH2 | |
| SCHEMBL6743988 | 0.75 | CTSV (0.64) | MAOBMAOATRPM8CTSVCTSL | |
| SCHEMBL7132711 | 0.75 | MAPK10 (0.64) | CA1CA2CA4CA6CCNB2 | |
| SCHEMBL2300747 | 0.75 | CA1 (1.00) | CA1CA2CA4CA6CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082319-B1 | BENZOCARBAZOLE AND INDENOINDOLE DERIVED ESTROGENIC AGENTS | WYETH CORP (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6159959-A | Combined estrogen and antiestrogen therapy | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| US-6107292-A | HORMONE REPLACEMENT THERAPY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-22 | — | — | US | disclosed |
| US-6069153-A | HORMONE REPLACEMENT THERPAY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-30 | — | — | US | disclosed |