Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.64 |
| ▸ | PDE4A | P27815 | 9/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | VEGFA | P15692 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PDE1A | P54750 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367046 | 0.92 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9167416 | 0.86 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9062953 | 0.84 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL6322653 | 0.82 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL1572502 | 0.80 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1572976 | 0.80 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7094968 | 0.80 | PDE4B (0.87) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7438600 | 0.80 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL27481581 | 0.79 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9325839 | 0.78 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732561-A1 | COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2006-12-20 | — | — | EP | disclosed |
| EP-1718613-A1 | PYRIDINE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080342-A1 | PYRIDINE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005074939-A1 | COMBINATION OF CB2 MODULATORS AND PDE4 INHIBITORS FOR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
| EP-1194142-A4 | SALTS OF CIS -4-CYANO-4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL) CYCLOHEXAN-1-CARBOXYLATE! | SMITHKLINE BEECHAM CORP (US) | 2002-10-25 | — | — | EP | disclosed |
| EP-1194142-A1 | SALTS OF CIS -4-CYANO-4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL) CYCLOHEXAN-1-CARBOXYLATE! | SmithKline Beecham Corporation (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000071114-A1 | SALTS OF CIS-[4-CYANO-4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)CYCLOHEXAN-1-CARBOXYLATE] | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-30 | — | — | WO | disclosed |