Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.44 |
| ▸ | METAP2 | P50579 | 5/20 | 0.36 |
| ▸ | METAP1 | P53582 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709584 | 0.83 | REN (0.41) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL7339021 | 0.83 | REN (0.40) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL7333758 | 0.83 | REN (0.40) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL9437488 | 0.83 | REN (0.40) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL10767496 | 0.80 | REN (0.42) | RENMETAP2METAP1CTSLCTSB | |
| Trifluoroacetic Acid SCHEMBL5709566 | 0.79 | REN (0.46) | RENMETAP2METAP1 | |
| SCHEMBL7331754 | 0.79 | REN (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7331477 | 0.77 | REN (0.42) | RENMETAP2METAP1 | |
| SCHEMBL7333234 | 0.77 | REN (0.39) | RENMETAP2METAP1CTSLCTSB | |
| SCHEMBL7279876 | 0.75 | REN (0.55) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1712227-A1 | Amino diols useful in the treatment of Alzheimer's disease | Elan Pharmaceuticals, Inc. (US) | 2006-10-18 | — | — | EP | claimed |
| US-20050080141-A1 | Amino diols useful in the treatment of alzheimer's disease | SCHOSTAREZ HEINRICH J (US) | 2005-04-14 | — | — | US | claimed |
| US-5229369-A | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | claimed |
| WO-1990000050-A1 | AMINOALKYLAMINOCARBONYL AMINODIOL AMINO ACID DERIVATIVES AS ANTI-HYPERTENSIVE AGENTS | G.D. SEARLE & CO. (US) | 1990-01-11 | — | — | WO | claimed |
| EP-0349922-A2 | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | claimed |
| EP-1712227-A1 | Amino diols useful in the treatment of Alzheimer's disease | Elan Pharmaceuticals, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| US-20050080141-A1 | Amino diols useful in the treatment of alzheimer's disease | SCHOSTAREZ HEINRICH J (US) | 2005-04-14 | — | — | US | disclosed |
| US-5229369-A | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1993002667-A1 | PHARMACEUTICAL COMPOSITION | ABBOTT LABORATORIES (US) | 1993-02-18 | — | — | WO | disclosed |
| WO-1990000050-A1 | AMINOALKYLAMINOCARBONYL AMINODIOL AMINO ACID DERIVATIVES AS ANTI-HYPERTENSIVE AGENTS | G.D. SEARLE & CO. (US) | 1990-01-11 | — | — | WO | disclosed |
| EP-0349922-A2 | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents | G.D. Searle & Co. (US) | 1990-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080141-A1 | Amino diols useful in the treatment of alzheimer's disease | BACE1, BACE2, APP | REN 2199/4885METAP2 55/4885METAP1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.