Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386762 | 0.79 | LMNA (0.41) | KDM4ENPSR1TSHRAPAF1HSD17B10 | |
| SCHEMBL13866502 | 0.78 | CNR2 (0.42) | KDM4ENPSR1TSHRAPAF1HSD17B10 | |
| SCHEMBL528739 | 0.76 | LMNA (0.44) | TSHROPRM1LMNACCR5HPGD | |
| SCHEMBL528126 | 0.74 | LMNA (0.40) | KDM4ETSHROPRM1LMNACCR5 | |
| SCHEMBL3809123 | 0.74 | NPSR1 (0.40) | KDM4ENPSR1TSHRAPAF1HSD17B10 | |
| SCHEMBL3809451 | 0.74 | NPSR1 (0.40) | KDM4ENPSR1TSHRAPAF1HSD17B10 | |
| SCHEMBL9001874 | 0.73 | OPRM1 (0.45) | KDM4ETSHROPRM1LMNACCR5 | |
| SCHEMBL3809121 | 0.72 | NPSR1 (0.41) | KDM4ENPSR1LMNAMAPTPKM | |
| SCHEMBL3809446 | 0.72 | NPSR1 (0.41) | KDM4ENPSR1LMNAMAPTPKM | |
| SCHEMBL2157448 | 0.71 | NPSR1 (0.42) | KDM4ENPSR1TSHRAPAF1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1710231-A1 | CETP activity inhibitors | Japan Tobacco, Inc. (JP) | 2006-10-11 | — | — | EP | disclosed |
| EP-1603553-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | JAPAN TOBACCO INC. (JP) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004082593-A2 | PHARMACEUTICAL COMPOSITIONS OF CETP INHIBITORS | JAPAN TOBACCO INC. (JP) | 2004-09-30 | — | — | WO | disclosed |