Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.59 |
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 14/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MST1R | Q04912 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958254 | 0.93 | MET (0.59) | METAXLKDRPDGFRB | |
| SCHEMBL1136995 | 0.85 | MET (0.60) | METAXLKDRCYP3A4PLK4 | |
| SCHEMBL1136770 | 0.84 | MET (0.64) | METAXLKDRCYP3A4PLK4 | |
| SCHEMBL9958340 | 0.83 | MET (0.52) | METKDRCYP3A4 | |
| SCHEMBL1137038 | 0.83 | RAF1 (0.65) | METAXLKDRPDGFRB | |
| SCHEMBL4330531 | 0.82 | MET (0.55) | METAXLKDRCYP3A4PLK4 | |
| SCHEMBL4328614 | 0.80 | MET (0.55) | METAXLKDRCYP3A4 | |
| SCHEMBL4326362 | 0.79 | MET (0.52) | METAXLKDRCYP3A4PLK4 | |
| SCHEMBL1136852 | 0.79 | MET (0.53) | METAXLKDRPLK4MAP4K4 | |
| SCHEMBL13861007 | 0.78 | KDR (0.65) | METAXLKDRMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1719763-A1 | NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (2) | Eisai Co., Ltd. (JP) | 2006-11-08 | — | — | EP | disclosed |