Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | FLT4 | P35916 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544093 | 0.81 | MEN1 (0.50) | MEN1KMT2AABL1PDGFRBBCR | |
| SCHEMBL544201 | 0.81 | RAB9A (0.48) | ABL1PDGFRBBCRPDGFRAPRKCA | |
| SCHEMBL543623 | 0.79 | BRAF (0.54) | MEN1KMT2AABL1PDGFRBBCR | |
| SCHEMBL544504 | 0.78 | ABL1 (0.58) | ABL1PDGFRBBCRPDGFRAPRKCA | |
| SCHEMBL13380736 | 0.76 | KIT (0.43) | MEN1KMT2AABL1PDGFRBBCR | |
| SCHEMBL544627 | 0.76 | ROCK2 (0.47) | MEN1KMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL3299706 | 0.76 | SMN1; SMN2 (0.51) | MEN1KMT2AABL1PDGFRBBCR | |
| SCHEMBL544048 | 0.76 | MAPK14 (0.46) | ABL1PDGFRBBCRPDGFRAPRKCA | |
| SCHEMBL544655 | 0.75 | KCNQ3 (0.47) | ABL1PDGFRBBCRPDGFRAPOLB | |
| SCHEMBL543692 | 0.75 | ROCK2 (0.46) | MEN1KMT2AABL1BCRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684750-A2 | 2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS | AB Science (FR) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005040139-A2 | 2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2005-05-06 | — | — | WO | disclosed |