Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 4/20 | 0.43 |
| ▸ | POR | P16435 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571381 | 0.83 | NQO1 (0.38) | NQO1PORMAOAMAOBMAPT | |
| SCHEMBL570963 | 0.80 | MAPT (0.45) | NQO1PORMAOAMAOBMAPT | |
| SCHEMBL571247 | 0.80 | MALT1 (0.41) | MAOAMAOBALDH1A1L3MBTL1KDM4E | |
| SCHEMBL9714008 | 0.79 | XIAP (0.46) | NQO1PORMAPTALDH1A1LMNA | |
| SCHEMBL571268 | 0.79 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4ETDP1MAPK1 | |
| SCHEMBL571496 | 0.78 | MAPT (0.56) | MAPTALDH1A1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL5808549 | 0.78 | MAOA (0.56) | NQO1PORMAOAMAOBMAPT | |
| SCHEMBL30002616 | 0.78 | MAOA (0.56) | NQO1PORMAOAMAOBMAPT | |
| SCHEMBL571964 | 0.77 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4ETDP1MAPK1 | |
| SCHEMBL571073 | 0.77 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4ETDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015183985-A2 | THERAPEUTIC COMPOSITIONS INCLUDING NAPHTHOQUINONES AND USES THEREOF | STEALTH PEPTIDES INTERNATIONAL, INC. (MC) | 2015-12-03 | — | — | WO | disclosed |
| EP-2600857-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | Edison Pharmaceuticals, Inc. (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012019029-A2 | TREATMENT OF MITOCHONDRIAL DISEASES WITH NAPHTHOQUINONES | EDISON PHARMACEUTICALS, INC. (US) | 2012-02-09 | — | — | WO | disclosed |