Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713501 | 1.00 | SIGMAR1 (0.42) | SIGMAR1MC4RALDH1A1MEN1KMT2A | |
| SCHEMBL1335893 | 0.87 | SMN1; SMN2 (0.41) | SIGMAR1MEN1KMT2AHRH3POLB | |
| SCHEMBL1335891 | 0.87 | SMN1; SMN2 (0.41) | SIGMAR1MEN1KMT2AHRH3POLB | |
| SCHEMBL5713440 | 0.85 | SIGMAR1 (0.50) | SIGMAR1MC4RALDH1A1MEN1KMT2A | |
| SCHEMBL5713495 | 0.85 | HPGD (0.45) | SIGMAR1MC4RALDH1A1MEN1KMT2A | |
| SCHEMBL6052744 | 0.81 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL5713520 | 0.80 | HRH3 (0.52) | SIGMAR1MC4RALDH1A1MEN1KMT2A | |
| SCHEMBL5713485 | 0.79 | HRH3 (0.55) | SIGMAR1MC4RALDH1A1HRH3SMN1; SMN2 | |
| SCHEMBL491723 | 0.75 | HRH3 (0.61) | SIGMAR1ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL491586 | 0.75 | HRH3 (0.61) | SIGMAR1ALDH1A1MEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863487-B1 | TREATMENT OF SYMPTOMS OF PARKINSON'S DISEASE WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2013-05-29 | — | — | EP | claimed |
| EP-1428820-B1 | Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications | BIOPROJET SOC CIV (FR) | 2006-05-17 | — | — | EP | claimed |
| EP-1100503-B1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ILE BIOPROJET SOC CIV (FR) | 2004-09-22 | — | — | EP | claimed |