Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713495 | 0.86 | HPGD (0.45) | SIGMAR1MC4RHRH3ALDH1A1GAA | |
| SCHEMBL5713501 | 0.85 | SIGMAR1 (0.42) | SIGMAR1MC4RHRH3ALDH1A1MEN1 | |
| SCHEMBL5713432 | 0.85 | SIGMAR1 (0.42) | SIGMAR1MC4RHRH3ALDH1A1MEN1 | |
| SCHEMBL5713520 | 0.85 | HRH3 (0.52) | SIGMAR1MC4RHRH3ALDH1A1MEN1 | |
| SCHEMBL5713485 | 0.83 | HRH3 (0.55) | SIGMAR1MC4RHRH3ALDH1A1RAB9A | |
| SCHEMBL6052744 | 0.82 | SIGMAR1 (0.44) | SIGMAR1HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL6566709 | 0.78 | HRH3 (0.46) | SIGMAR1MC4RHRH3ALDH1A1MEN1 | |
| SCHEMBL491564 | 0.75 | SIGMAR1 (0.76) | SIGMAR1ACHEHRH3ALDH1A1USP2 | |
| SCHEMBL6570100 | 0.75 | SIGMAR1 (0.51) | SIGMAR1ACHEMC4RALDH1A1GAA | |
| SCHEMBL1335891 | 0.73 | SMN1; SMN2 (0.41) | SIGMAR1HRH3GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863487-B1 | TREATMENT OF SYMPTOMS OF PARKINSON'S DISEASE WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2013-05-29 | — | — | EP | claimed |
| CN-101171009-A | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3- receptor ligands | BIOPROJET SOC CIV (FR) | 2008-04-30 | — | — | CN | claimed |
| EP-1428820-B1 | Non-imidazole alkylamines as histamine H-3-receptor ligands and their therapeutic applications | BIOPROJET SOC CIV (FR) | 2006-05-17 | — | — | EP | claimed |
| EP-1100503-B1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ILE BIOPROJET SOC CIV (FR) | 2004-09-22 | — | — | EP | claimed |
| CN-101171009-B | Use of non-imidazole alkylamines histamine h3- receptor ligands in treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia | BIOPROJET SOC CIV | 2012-11-07 | — | — | CN | disclosed |
| CN-101171009-A | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3- receptor ligands | BIOPROJET SOC CIV (FR) | 2008-04-30 | — | — | CN | disclosed |