Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161959 | 0.90 | HRH3 (0.42) | HRH3HRH1IDH1OPRM1OPRD1 | |
| SCHEMBL5160920 | 0.85 | HRH3 (0.56) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5713471 | 0.84 | HRH3 (0.39) | HRH3HRH1CNR2IDH1ADRA1A | |
| SCHEMBL5713465 | 0.83 | HRH3 (0.39) | HRH3 | |
| SCHEMBL5713459 | 0.79 | GHSR (0.44) | HRH3 | |
| SCHEMBL4923707 | 0.78 | NR1H2 (0.46) | HRH3HRH1CNR2 | |
| SCHEMBL5551729 | 0.76 | ESR1 (0.47) | — | |
| SCHEMBL5713443 | 0.76 | HRH3 (0.39) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5161049 | 0.76 | HRH3 (0.39) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5161964 | 0.74 | HRH3 (0.40) | HRH3HRH1IDH1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735299-A1 | TERTRAHYDROBENZAZEPINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097778-A1 | TETRAHYDROBENZAZEPINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2005-10-20 | — | — | WO | disclosed |