Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713471 | 0.90 | HRH3 (0.39) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5160929 | 0.89 | HRH3 (0.53) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5161959 | 0.85 | HRH3 (0.42) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5713447 | 0.84 | HRH3 (0.37) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5158952 | 0.82 | HRH3 (0.43) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5161059 | 0.81 | OPRM1 (0.41) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL5159383 | 0.79 | STAT3 (0.37) | OPRM1OPRD1OPRK1KDM4C | |
| SCHEMBL5713479 | 0.79 | HRH3 (0.46) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL6223629 | 0.78 | HRH3 (0.54) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5713467 | 0.77 | HRH3 (0.38) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756094-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1735299-A1 | TERTRAHYDROBENZAZEPINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005123723-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005097778-A1 | TETRAHYDROBENZAZEPINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2005-10-20 | — | — | WO | disclosed |