Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | MEN1 | O00255 | 6/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.74 |
| ▸ | TP53 | P04637 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | KLK7 | P49862 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10564727 | 0.89 | MAPT (0.60) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL27039869 | 0.88 | MAPT (0.58) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL10655498 | 0.88 | ALDH1A1 (0.65) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL4680788 | 0.88 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL29550916 | 0.86 | MAPT (0.63) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL28730377 | 0.86 | MAPT (0.63) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL29550908 | 0.85 | MAPT (0.73) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL4293075 | 0.85 | ALDH1A1 (0.69) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL28443416 | 0.85 | MAPT (0.73) | MAPTALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL571684 | 0.85 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574490-B | Synthesis method of polyhydroxy isoflavone | 中国人民解放军联勤保障部队第九〇四医院 | 2022-04-29 | — | — | CN | claimed |
| CN-111574490-B | Synthesis method of polyhydroxy isoflavone | 中国人民解放军联勤保障部队第九〇四医院 | 2022-04-29 | — | — | CN | disclosed |
| CN-111574490-A | Synthesis method of polyhydroxy isoflavone | 中国人民解放军联勤保障部队第九〇四医院 | 2020-08-25 | — | — | CN | disclosed |
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-08-21 | — | — | US | disclosed |
| US-8748177-B2 | Compositions for proliferation of cells and related methods | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-06-10 | — | — | US | disclosed |
| EP-2598150-A2 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | The Hospital For Sick Children (CA) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012018643-A2 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2012-02-09 | — | — | WO | disclosed |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2011-12-08 | — | — | US | disclosed |
| WO-2010039679-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140234271-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | MAPT 2714/4885ALDH1A1 1070/4885MEN1 4189/4885 |
| US-20110301105-A1 | COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS | MKI67, KRT18, PROX1 | MAPT 2714/4885ALDH1A1 1070/4885MEN1 4189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.