Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 6/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101747 | 0.98 | SIGMAR1 (0.47) | SIGMAR1ADORA3HTR2AHTR7OPRM1 | |
| SCHEMBL6101400 | 0.97 | KDM4E (0.44) | KDM4EALDH1A1HRH2HRH1POLB | |
| SCHEMBL5715177 | 0.92 | SIGMAR1 (0.44) | SIGMAR1ADORA3HTR2AHTR7OPRM1 | |
| SCHEMBL5714749 | 0.90 | KDM4E (0.44) | KDM4EALDH1A1HRH2HRH1POLB | |
| SCHEMBL6103531 | 0.89 | KDM4E (0.54) | KDM4EALDH1A1POLB | |
| SCHEMBL5715419 | 0.87 | KDM4E (0.47) | SIGMAR1ADORA3HTR2AHTR7OPRM1 | |
| SCHEMBL5715316 | 0.86 | KDM4E (0.46) | SIGMAR1ADORA3HTR2AHTR7OPRM1 | |
| SCHEMBL5714683 | 0.85 | SIGMAR1 (0.46) | SIGMAR1ADORA3HTR2AHTR7OPRM1 | |
| SCHEMBL5714888 | 0.85 | KDM4E (0.47) | SIGMAR1ADORA3HTR2AHTR7OPRM1 | |
| SCHEMBL5714479 | 0.85 | SIGMAR1 (0.47) | SIGMAR1ADORA3HTR2AHTR7OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006527212-A | — | — | 2006-11-30 | — | — | JP | claimed |
| EP-1636187-A1 | SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2006-03-22 | — | — | EP | claimed |
| WO-2004111004-A1 | SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-12-23 | — | — | WO | claimed |
| EP-1636187-A1 | SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004111004-A1 | SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-12-23 | — | — | WO | disclosed |