Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 6/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6102814 | 0.98 | KDM4E (0.47) | KDM4EALDH1A1ALOX15FAAHSIGMAR1 | |
| SCHEMBL6103006 | 0.97 | THRB (0.41) | KDM4EALDH1A1ALOX15DRD2POLB | |
| SCHEMBL5715116 | 0.91 | KDM4E (0.45) | KDM4EALDH1A1ALOX15FAAHSIGMAR1 | |
| SCHEMBL5715407 | 0.90 | KDM4E (0.41) | KDM4EALDH1A1ALOX15DRD2HRH2 | |
| SCHEMBL6102352 | 0.89 | KDM4E (0.50) | KDM4EALDH1A1POLB | |
| SCHEMBL5714798 | 0.88 | SIGMAR1 (0.47) | FAAHSIGMAR1ADORA3HTR2AHTR7 | |
| SCHEMBL6102347 | 0.86 | KCNH2 (0.43) | KDM4EFAAHSIGMAR1ADORA3HTR2A | |
| SCHEMBL5714855 | 0.86 | DRD2 (0.47) | SIGMAR1ADORA3HTR2AHTR7OPRM1 | |
| SCHEMBL5714136 | 0.86 | SIGMAR1 (0.45) | KDM4EALDH1A1ALOX15FAAHSIGMAR1 | |
| SCHEMBL5715419 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1ALOX15FAAHSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636187-A1 | SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004111004-A1 | SUBSTITUTED PIPERAZINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-12-23 | — | — | WO | disclosed |