Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5715341 | 0.87 | DRD1 (0.46) | PTGS2DRD1MAPTHSD17B10PTGDR2 | |
| SCHEMBL5715331 | 0.86 | PTGS2 (0.50) | PTGS2DRD1PTGDR2ERN1HTT | |
| SCHEMBL1778039 | 0.82 | HSD17B10 (0.65) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL5715406 | 0.80 | PTGER1 (0.52) | PTGS2DRD1MEN1KMT2APTGDR2 | |
| SCHEMBL14569174 | 0.79 | CA12 (0.61) | PTGS2MEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL15210310 | 0.78 | SMN1; SMN2 (0.59) | PTGS2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5715568 | 0.77 | PTGS2 (0.69) | PTGS2PDE4BPOLBHPGDMAPK1 | |
| SCHEMBL27814160 | 0.77 | KDM4E (0.60) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL17127349 | 0.77 | NQO1 (0.56) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL5715411 | 0.76 | PTGS2 (0.45) | PTGS2POLBPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434762-B1 | 4'-METHANESULFONYL-BIPHENYL DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CHEIL JEDANG CORP (KR) | 2006-12-20 | — | — | EP | claimed |
| US-6583321-B1 | Nonsteroid, antiinflammatory; side effect reduction | CHEIL JEDANG CORPORATION (KR) | 2003-06-24 | — | — | US | claimed |
| US-20030105095-A1 | 4'-Methanesulfonyl-biphenyl derivatives as a highly selective cyclooxygenase-2 inhibitor | CHEIL JEDANG CORPORATION (KR) | 2003-06-05 | — | — | US | claimed |
| EP-1434762-B1 | 4'-METHANESULFONYL-BIPHENYL DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CHEIL JEDANG CORP (KR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1434762-A4 | 4'-METHANESULFONYL-BIPHENYL DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CHEIL JEDANG CORP (KR) | 2006-01-04 | — | — | EP | disclosed |
| EP-1434762-A1 | 4'-METHANESULFONYL-BIPHENYL DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | Cheil Jedang Corporation (KR) | 2004-07-07 | — | — | EP | disclosed |
| US-6583321-B1 | Nonsteroid, antiinflammatory; side effect reduction | CHEIL JEDANG CORPORATION (KR) | 2003-06-24 | — | — | US | disclosed |
| US-20030105095-A1 | 4'-Methanesulfonyl-biphenyl derivatives as a highly selective cyclooxygenase-2 inhibitor | CHEIL JEDANG CORPORATION (KR) | 2003-06-05 | — | — | US | disclosed |
| WO-2003031398-A1 | 4'-METHANESULFONYL-BIPHENYL DERIVATIVES AS A HIGHLY SELECTIVE CYCLOOXYGENASE-2 INHIBITOR | CHEIL JEDANG CORPORATION (KR) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105095-A1 | 4'-Methanesulfonyl-biphenyl derivatives as a highly selective cyclooxygenase-2 inhibitor | PTGS1, PTGS2, PTGES2 | PTGS2 2/4885PDE4A 2363/4885PDE4B 2102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.