Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 3/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.53 |
| ▸ | MMP8 | P22894 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CETP | P11597 | 1/20 | 0.51 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5716710 | 1.00 | RAB9A (0.56) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL5378778 | 0.86 | RAB9A (0.70) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL12393102 | 0.77 | MMP2 (0.64) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL2245219 | 0.76 | MMP2 (0.85) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL7908000 | 0.75 | RAB9A (0.84) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL25989653 | 0.75 | RAB9A (0.70) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL3202508 | 0.75 | RAB9A (0.70) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL16894054 | 0.74 | RAB9A (0.69) | RAB9ANPC1MAPTALDH1A1MMP2 | |
| SCHEMBL7695426 | 0.73 | GAA (0.49) | RAB9ANPC1MAPTALDH1A1MEN1 | |
| SCHEMBL27188288 | 0.73 | PPARG (0.78) | MAPTRXFP1PPARGCYP2C8NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725524-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005092845-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-10-06 | — | — | WO | disclosed |