Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.62 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717089 | 0.91 | ALDH1A1 (0.58) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5717267 | 0.88 | ALDH1A1 (0.55) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5717094 | 0.88 | HCRTR1 (0.61) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5717121 | 0.88 | ALDH1A1 (0.56) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5717057 | 0.85 | HCRTR1 (0.60) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5717024 | 0.84 | HCRTR1 (0.64) | HCRTR1HCRTR2ALDH1A1MEN1KMT2A | |
| SCHEMBL5717026 | 0.84 | FKBP1A (0.50) | HCRTR1HCRTR2ALDH1A1KDM4EFKBP1A | |
| SCHEMBL5717227 | 0.83 | ALDH1A1 (0.64) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5717102 | 0.83 | ALDH1A1 (0.64) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5717100 | 0.83 | ALDH1A1 (0.64) | HCRTR1HCRTR2ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664010-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005068448-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-07-28 | — | — | WO | disclosed |