Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.74 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.68 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.68 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.68 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.68 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.68 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11959875 | 0.85 | HSD11B1 (1.00) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13036462 | 0.85 | HSD11B1 (1.00) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11959849 | 0.85 | HSD11B1 (1.00) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL26079698 | 0.84 | BRD4 (0.73) | HSD11B1AKR1C3KMT2AALDH1A1MEN1 | |
| SCHEMBL23806103 | 0.84 | BRD4 (0.73) | HSD11B1AKR1C3KMT2AALDH1A1MEN1 | |
| SCHEMBL2305949 | 0.84 | HSD11B1 (0.58) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14298935 | 0.82 | ACHE (0.68) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12169388 | 0.82 | ACHE (0.68) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5717132 | 0.82 | PSEN1 (0.70) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3116741 | 0.82 | PSEN1 (0.75) | HSD11B1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664010-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005068448-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-07-28 | — | — | WO | disclosed |