Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.36 |
| ▸ | THRB | P10828 | 12/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | NPY2R | P49146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717774 | 0.90 | THRB (0.44) | THRATHRB | |
| SCHEMBL5717853 | 0.83 | THRA (0.37) | THRATHRBMEN1KMT2A | |
| SCHEMBL5717738 | 0.82 | THRA (0.40) | THRATHRBMEN1KMT2A | |
| SCHEMBL4926484 | 0.81 | THRA (0.55) | THRATHRB | |
| SCHEMBL4926593 | 0.81 | FFAR4 (0.42) | THRATHRB | |
| SCHEMBL4929566 | 0.81 | THRA (0.52) | THRATHRB | |
| SCHEMBL5717860 | 0.81 | KMT2A (0.33) | THRATHRBMEN1KMT2AMAPT | |
| SCHEMBL4932662 | 0.80 | THRA (0.41) | THRATHRB | |
| SCHEMBL5717950 | 0.80 | THRA (0.44) | THRATHRB | |
| SCHEMBL5717758 | 0.80 | KMT2A (0.35) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |