Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717732 | 0.93 | TSHR (0.77) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL5717754 | 0.89 | TSHR (0.84) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL5204786 | 0.84 | ALDH1A1 (0.62) | LMNARAB9ANPC1TSHRHDAC2 | |
| SCHEMBL14735987 | 0.84 | NOTUM (0.65) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL5717662 | 0.83 | TSHR (1.00) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL20029259 | 0.81 | SIRT2 (0.91) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL28869626 | 0.81 | SIRT2 (0.75) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL14735989 | 0.79 | NOTUM (0.76) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL19287059 | 0.79 | SIRT2 (0.68) | LMNARAB9ANPC1TSHRSIRT2 | |
| SCHEMBL7977108 | 0.78 | ALDH1A1 (0.69) | LMNARAB9ANPC1TSHRHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| US-20060211636-A1 | Macrolide Antibiotics | ALIHODZIC SULEJMAN | 2006-09-21 | — | — | US | disclosed |
| US-20050215495-A1 | Macrolide antibiotics | ALIHODZIC SULEJMAN | 2005-09-29 | — | — | US | disclosed |
| US-20040077557-A1 | Macrolide antibiotics | GLAXO GROUP LIMITED (GB) | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215495-A1 | Macrolide antibiotics | IL1R1, MRPL12, RPS21 | LMNA 1672/4885RAB9A 1478/4885NPC1 122/4885 |
| US-20060211636-A1 | Macrolide Antibiotics | IL1R1, MRPL12, RPS21 | LMNA 1672/4885RAB9A 1478/4885NPC1 122/4885 |
| US-20040077557-A1 | Macrolide antibiotics | MALT1, MRPL21, IL1R1 | LMNA 1504/4885RAB9A 1258/4885NPC1 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.