Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717662 | 0.92 | TSHR (1.00) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL5717832 | 0.89 | LMNA (0.73) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL562989 | 0.87 | ALDH1A1 (1.00) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL24326607 | 0.86 | ALDH1A1 (0.77) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL27608362 | 0.85 | ALDH1A1 (0.75) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL5717742 | 0.84 | ALDH1A1 (0.79) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL5717732 | 0.82 | TSHR (0.77) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL20029259 | 0.81 | SIRT2 (0.91) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL28869626 | 0.81 | SIRT2 (0.75) | TSHRALDH1A1LMNANPC1RAB9A | |
| SCHEMBL27429874 | 0.80 | TSHR (0.69) | TSHRALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| CN-1492874-A | Macrolide antibiotics | — | 2004-04-28 | — | — | CN | disclosed |