Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.33 |
| ▸ | THRB | P10828 | 7/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717863 | 0.90 | THRA (0.41) | THRATHRBCACNA1IF10KCNH2 | |
| SCHEMBL5717883 | 0.89 | THRA (0.38) | THRATHRBF10CRHR1 | |
| SCHEMBL5717853 | 0.86 | THRA (0.37) | THRATHRB | |
| SCHEMBL4934616 | 0.86 | CACNA1I (0.35) | CACNA1IF10KCNH2CRHR1CACNA1G | |
| SCHEMBL4923398 | 0.84 | THRA (0.48) | THRATHRB | |
| SCHEMBL5717857 | 0.83 | THRA (0.39) | THRATHRBCACNA1IF10KCNH2 | |
| SCHEMBL5717918 | 0.80 | THRB (0.37) | THRATHRB | |
| SCHEMBL5717844 | 0.79 | THRA (0.36) | THRATHRBF10 | |
| SCHEMBL5717878 | 0.78 | THRA (0.46) | THRATHRB | |
| SCHEMBL5717989 | 0.78 | THRA (0.35) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |