Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.54 |
| ▸ | THRA | P10827 | 18/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345996 | 0.91 | THRB (0.57) | THRBTHRAPPARGESR1NR3C1 | |
| SCHEMBL4925262 | 0.89 | THRB (0.42) | THRBTHRAS1PR2S1PR1S1PR3 | |
| SCHEMBL4923163 | 0.89 | THRB (0.62) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL4927717 | 0.88 | THRB (0.54) | THRBTHRAPPARGESR1NR3C1 | |
| SCHEMBL4934000 | 0.88 | THRB (0.54) | THRBTHRAPPARGESR1NR3C1 | |
| SCHEMBL4931778 | 0.85 | THRB (0.56) | THRBTHRAPPARGESR1NR3C1 | |
| SCHEMBL4933325 | 0.85 | THRB (0.43) | THRBTHRA | |
| SCHEMBL4932092 | 0.85 | THRB (0.51) | THRBTHRA | |
| SCHEMBL4923070 | 0.85 | THRB (0.66) | THRBTHRAESR1NR3C1PGR | |
| SCHEMBL4930926 | 0.84 | THRB (0.50) | THRBTHRAPPARGESR1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |