Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720125 | 0.91 | CHRM1 (0.41) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL5720132 | 0.89 | TRPV6 (0.41) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL5720312 | 0.88 | DRD2 (0.40) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL5720263 | 0.88 | CHRM1 (0.38) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL5720385 | 0.86 | CHRM1 (0.53) | CHRM1DRD2KMT2AALDH1A1TRPV6 | |
| SCHEMBL5720197 | 0.84 | CHRM1 (0.51) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL5720279 | 0.83 | DRD2 (0.41) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL5720269 | 0.83 | DRD2 (0.39) | DRD2DRD4DRD3ALDH1A1TRPV6 | |
| SCHEMBL5720388 | 0.82 | DRD2 (0.40) | DRD2DRD4DRD3TRPV6KDM4E | |
| SCHEMBL5719999 | 0.81 | CHRM2 (0.45) | DRD2CHRM2CHRM3DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515722-A4 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO INC (US) | 2006-06-21 | — | — | EP | disclosed |
| EP-1515722-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003105781-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2003-12-24 | — | — | WO | disclosed |