Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6010495 | 0.85 | HTT (0.40) | MDM4TP53HTTKMT2ANPSR1 | |
| SCHEMBL2906720 | 0.79 | MAPT (0.39) | MDM4TP53KMT2AMAPTALDH1A1 | |
| SCHEMBL1058528 | 0.73 | MAPT (0.39) | KMT2AMAPTALDH1A1 | |
| SCHEMBL1058524 | 0.73 | MAPT (0.38) | MDM4TP53MAPTALDH1A1 | |
| SCHEMBL2435295 | 0.72 | MAPT (0.37) | MDM4TP53MAPTALDH1A1 | |
| SCHEMBL2435292 | 0.72 | MAPT (0.38) | MAPTALDH1A1MDM2 | |
| SCHEMBL9449395 | 0.71 | KMT2A (0.46) | MDM4TP53KMT2A | |
| SCHEMBL1253102 | 0.69 | CASP3 (0.54) | MDM4TP53KMT2A | |
| SCHEMBL13946516 | 0.69 | CASP3 (0.54) | MDM4TP53KMT2A | |
| SCHEMBL14940666 | 0.69 | CASP3 (0.54) | MDM4TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697348-A1 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061487-A1 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2005-07-07 | — | — | WO | disclosed |