Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720459 | 0.85 | MDM4 (0.37) | HTTMDM2NPSR1MDM4TP53 | |
| SCHEMBL3801396 | 0.80 | RECQL (0.38) | MDM2RECQLKMT2A | |
| SCHEMBL20550069 | 0.74 | KMT2A (0.43) | MDM4TP53KMT2A | |
| SCHEMBL2438216 | 0.73 | MAPT (0.37) | RECQLKMT2A | |
| SCHEMBL2438220 | 0.72 | MAPT (0.36) | MDM2RECQLMDM4TP53 | |
| SCHEMBL1564185 | 0.71 | CASP3 (0.52) | MDM2MDM4TP53KMT2A | |
| SCHEMBL1486214 | 0.71 | CASP3 (0.52) | MDM2MDM4TP53KMT2A | |
| SCHEMBL1486287 | 0.71 | CASP3 (0.52) | MDM2MDM4TP53KMT2A | |
| SCHEMBL6038102 | 0.71 | CASP3 (0.52) | MDM2MDM4TP53KMT2A | |
| SCHEMBL119497 | 0.71 | CASP3 (0.52) | MDM2MDM4TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697344-A2 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058841-A2 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2005-06-30 | — | — | WO | disclosed |