Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 10/20 | 0.57 |
| ▸ | TNF | P01375 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720289 | 0.99 | FAAH (0.59) | FAAHTNFGAA | |
| SCHEMBL7972755 | 0.92 | FAAH (0.47) | FAAHTNFGAACYP1A2CYP2C9 | |
| SCHEMBL11127880 | 0.87 | FAAH (0.56) | FAAHGAACYP1A2CYP2C19 | |
| SCHEMBL8104091 | 0.86 | FAAH (0.62) | FAAHTNFGAA | |
| SCHEMBL5720217 | 0.84 | FABP4 (0.49) | FAAH | |
| SCHEMBL11714254 | 0.83 | TNF (0.57) | FAAHTNFGAA | |
| SCHEMBL8104133 | 0.83 | PTGIR (0.49) | FAAH | |
| SCHEMBL8111700 | 0.83 | PTGIR (0.49) | FAAH | |
| SCHEMBL11124513 | 0.83 | PTGIR (0.49) | FAAH | |
| SCHEMBL8103785 | 0.83 | PTGIR (0.49) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | claimed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | claimed |
| EP-0841910-A4 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2006-09-13 | — | — | EP | disclosed |
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| EP-0841910-A1 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |
| WO-1997004765-A1 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-13 | — | — | WO | disclosed |
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |