SCHEMBL5720522

SCHEMBL5720522

O=C1OC(=O)N2Cc3ccccc3CC12

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.46
ALDH1A1 P00352 3/20 0.44
RAB9A P51151 1/20 0.44
HTT P42858 1/20 0.44
SIGMAR1 Q99720 5/20 0.43
TSHR P16473 1/20 0.42
PARP1 P09874 1/20 0.41
GAA P10253 1/20 0.39
GRM4 Q14833 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30731231 1.00 ADORA2A (0.46) ADORA2AALDH1A1RAB9AHTTSIGMAR1
SCHEMBL24569651 1.00 ADORA2A (0.46) ADORA2AALDH1A1RAB9AHTTSIGMAR1
SCHEMBL4627301 1.00 ADORA2A (0.46) ADORA2AALDH1A1RAB9AHTTSIGMAR1
SCHEMBL3321300 0.70 ALDH1A1 (0.52) ADORA2AALDH1A1RAB9AHTTSIGMAR1
SCHEMBL30578815 0.69 PDE4B (0.57) ADORA2ARAB9ASIGMAR1PARP1
SCHEMBL22700093 0.69 PDE4B (0.57) ADORA2ARAB9ASIGMAR1PARP1
SCHEMBL6856036 0.69 ADORA2A (0.46) ADORA2AALDH1A1RAB9AHTTSIGMAR1
SCHEMBL14935698 0.68 ADORA2A (0.58) ADORA2AALDH1A1RAB9AHTTSIGMAR1
SCHEMBL14935697 0.68 ADORA2A (0.58) ADORA2AALDH1A1RAB9AHTTSIGMAR1
SCHEMBL6858194 0.67 ADORA2A (0.43) ADORA2AALDH1A1RAB9AHTTSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10291979-A None JP disclosed
WO-2022136366-A1 NOVEL METHOD FOR SYNTHESIZING NCA COMPOUNDS ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER (ENSCM) (FR) 2022-06-30 WO disclosed
EP-1543074-A4 UV-CURABLE RESIN COMPOSITION FOR CLADDING OPTICAL FIBER SSCP CO LTD (KR) 2006-01-04 EP disclosed
EP-1543074-A1 UV-CURABLE RESIN COMPOSITION FOR CLADDING OPTICAL FIBER SSCP Co., Ltd. (KR) 2005-06-22 EP disclosed
WO-2004024814-A1 UV-CURABLE RESIN COMPOSITION FOR CLADDING OPTICAL FIBER SSCP CO., LTD. (KR) 2004-03-25 WO disclosed
JP-H10291979-A PRODUCTION OF 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID TERTIARY BUTYL AMIDE ICHIKAWA GOSEI KAGAKU KK 1998-11-04 JP disclosed