Known targets — ChEMBL curated mechanism
DRD2DRD3DRD4GNRHRHRH1HTR2AHTR2CSLC6A2SLC6A4SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Pamoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | ME2 | P23368 | 1/20 | 0.76 |
| ▸ | ME1 | P48163 | 1/20 | 0.76 |
| ▸ | ME3 | Q16798 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.56 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | GALK1 | P51570 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamoic Acid SCHEMBL446833 | 1.00 | GPR35 (1.00) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL30293211 | 1.00 | GPR35 (1.00) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL30293206 | 1.00 | GPR35 (1.00) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL29362189 | 1.00 | GPR35 (1.00) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL991085 | 0.98 | GPR35 (0.97) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL9982931 | 0.98 | GPR35 (0.97) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL5175194 | 0.98 | GPR35 (0.97) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL1055608 | 0.98 | GPR35 (0.97) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL5012888 | 0.98 | GPR35 (0.97) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL15009319 | 0.98 | GPR35 (0.97) | GPR35POLBME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 139519 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120754262-B | Nucleic acid delivery vector and preparation method and application thereof | Shenzhen Jinlin Biotechnology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260137676-A1 | PIPERAZINE SUBSTITUTED PHENOL DERIVATIVE AND USE THEREOF | CHENGDU MFS PHARMA. CO., LTD. (CN) | 2026-05-21 | — | — | US | claimed |
| EP-4745137-A1 | GLUTARIMIDE ISOINDOLINONE SKELETON-BASED COMPOUND | Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) | 2026-05-20 | — | — | EP | claimed |
| EP-4745135-A1 | COMPOUND BASED ON THIO-GLUTARIMIDO ISOINDOLINONE SKELETON AND USE THEREOF | Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) | 2026-05-20 | — | — | EP | claimed |
| CN-122070275-A | Heterocyclic compound and application thereof | 成都麻沸散医药科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-12630551-B2 | Endocyclic pyrimidinone compounds, and preparation methods, compositions and use thereof | NEUSCO BIOTECH LIMITED (CN) | 2026-05-19 | — | — | US | claimed |
| CN-119978070-B | Cyclohexapeptide for skin care, and composition and application thereof | 深圳市维琪科技股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122070278-A | Bifunctional protein degradation agent containing aryl substituted heteroaryl and application thereof | 标新生物医药科技(上海)有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122036704-A | Free base crystal form or acid salt of biaryl compound, preparation method and medical application thereof | 江苏豪森药业集团有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122036801-A | Crystalline forms of tenofovir alafenamide | 吉利德科学公司 | 2026-05-15 | — | — | CN | claimed |
| US-4120762-A | POROUS SUPPORT IMPREGNATED WITH AN ELECTROLYTE, A MARKING COMPOUND AND A NITROGEN-CONTAINING SIX-MEMBERED HETEROCYCLIC AROMATIC CARBOXY ACID | ALDEN RESEARCH FOUNDATION (US) | 1978-10-17 | — | — | US | claimed |
| US-4117157-A | TREATMENT OF CARDIOVASCULAR DISORDERS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-09-26 | — | — | US | claimed |
| US-4115409-A | CARDIOVASCULAR DISORDERS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-09-19 | — | — | US | claimed |
| US-4076942-A | USEFUL IN LOWERING INTRAOCULAR PRESSURE IN GLAUCOMATOUS PATIENTS | MERCK & CO., INC. (US) | 1978-02-28 | — | — | US | claimed |
| US-4016273-A | Sustained release forms of certain oxazepines for parenteral administration | AMERICAN CYANAMID COMPANY (US) | 1977-04-05 | — | — | US | claimed |
| US-3983252-A | Stable dialdehyde-containing disinfectant compositions and methods | BUCHALTER GILBERT | 1976-09-28 | — | — | US | claimed |
| US-3966749-A | Novel synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols, the pharmaceutically acceptable acid addition salts thereof and intermediate useful in the preparation thereof | INTERX RESEARCH CORPORATION (US) | 1976-06-29 | — | — | US | claimed |
| US-3957978-A | ANTHELMINTICS | AMERICAN CYANAMID COMPANY (US) | 1976-05-18 | — | — | US | claimed |
| US-3957786-A | HYPOTENSIVE AGENTS | BYK GULDEN (DT) | 1976-05-18 | — | — | US | claimed |
| US-3956330-A | N,N-diethyl-4-methyl-1-pi-perazinecarboxamide pamoate | AMERICAN CYANAMID COMPANY (US) | 1976-05-11 | — | — | US | claimed |