Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454740 | 0.89 | HRH3 (0.36) | HRH3KDM4ETSHRHSD17B10USP2 | |
| SCHEMBL28399535 | 0.89 | USP2 (0.39) | HRH3KDM4ETSHRHSD17B10ALOX15 | |
| SCHEMBL5233749 | 0.84 | CHRNB2 (0.41) | HRH3HSD17B10ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5466976 | 0.84 | CHRNB2 (0.41) | HRH3HSD17B10ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28465611 | 0.77 | HRH3 (0.33) | HRH3 | |
| SCHEMBL28988542 | 0.76 | — | — | |
| SCHEMBL20853432 | 0.75 | SIGMAR1 (0.33) | KDM4ETSHRALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4042388 | 0.75 | HRH3 (0.42) | HRH3KDM4ETSHRHSD17B10ALOX15 | |
| SCHEMBL165786 | 0.72 | — | — | |
| SCHEMBL6780002 | 0.71 | MC4R (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115960080-A | Polycyclic compound and application thereof as ghrelin receptor agonist | 南京知和医药科技有限公司 | 2023-04-14 | — | — | CN | disclosed |
| EP-1670786-A1 | QUINAZOLINE DERIVATIVES | Astrazeneca AB (SE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005030757-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | disclosed |