Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.66 |
| ▸ | KIF11 | P52732 | 14/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304608 | 0.95 | SIRT1 (0.69) | SIRT1KIF11ABCG2TP53MAPT | |
| SCHEMBL3577188 | 0.89 | KIF11 (0.80) | KIF11 | |
| SCHEMBL11912895 | 0.89 | KIF11 (0.59) | SIRT1KIF11HTR2AHTR2CABCG2 | |
| SCHEMBL763586 | 0.87 | KIF11 (0.58) | SIRT1KIF11HTR2AHTR2CABCG2 | |
| SCHEMBL11912523 | 0.87 | KIF11 (0.58) | SIRT1KIF11HTR2AHTR2CABCG2 | |
| SCHEMBL764129 | 0.86 | ABCG2 (0.63) | SIRT1KIF11ABCG2TP53MAPT | |
| SCHEMBL11912526 | 0.86 | KIF11 (0.56) | SIRT1KIF11HTR2AHTR2CABCG2 | |
| SCHEMBL3574031 | 0.86 | KIF11 (0.66) | SIRT1KIF11HTR2AHTR2C | |
| SCHEMBL9962123 | 0.85 | KIF11 (0.56) | SIRT1KIF11HTR2AHTR2CABCG2 | |
| SCHEMBL8403284 | 0.85 | KIF11 (0.56) | SIRT1KIF11HTR2AHTR2CABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706404-A2 | TETRAHYDROCARBOLINE COMPOUNDS AS ANTICANCER AGENTS | Chiron Corporation (US) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005070930-A2 | TETRAHYDROCARBOLINE COMPOUNDS AS ANTICANCER AGENTS | CHIRON CORPORATION (US) | 2005-08-04 | — | — | WO | disclosed |