Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11185205 | 0.73 | MAPT (0.56) | POLBMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL14917192 | 0.72 | ALDH1A1 (0.41) | MAPTSMN1; SMN2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5722235 | 0.70 | HTT (0.52) | POLBMAPTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL11267717 | 0.69 | MAPT (0.78) | POLBMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL11180555 | 0.69 | L3MBTL1 (0.51) | POLBMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL11608011 | 0.69 | MAPT (0.51) | POLBMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL11358475 | 0.67 | KDM4E (0.53) | POLBLMNAL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL6218670 | 0.67 | ALDH1A1 (0.40) | POLBMAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1572767 | 0.67 | HTT (0.54) | POLBMAPTLMNACYP1A2CYP2D6 | |
| Isophthalic Acid SCHEMBL29023597 | 0.66 | CA12 (0.60) | POLBMAPTL3MBTL1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713543-A2 | USE OF SUBSTITUTED 1,2,3 INDOLIZINE DERIVATIVES FOR TREATING DISEASES ASSOCIATED WITH A PATHOLOGICAL ANGIOGENESIS | Sanofi-Aventis (FR) | 2006-10-25 | — | — | EP | claimed |
| WO-2005082457-A2 | USE OF SUBSTITUTED 1,2,3 INDOLIZINE DERIVATIVES FOR TREATING DISEASES ASSOCIATED WITH A PATHOLOGICAL CHOROIDAL ANGIOGENESIS | SANOFI-AVENTIS (FR) | 2005-09-09 | — | — | WO | claimed |