Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.48 |
| ▸ | THRB | P10828 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348053 | 0.96 | THRA (0.52) | THRATHRBSMN1; SMN2PDE5AMEN1 | |
| SCHEMBL4354704 | 0.95 | THRA (0.50) | THRATHRBSMN1; SMN2PDE5AMEN1 | |
| SCHEMBL5722506 | 0.92 | THRA (0.43) | THRATHRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5722640 | 0.84 | THRA (0.48) | THRATHRBSMN1; SMN2ARESR1 | |
| SCHEMBL5119167 | 0.84 | SMN1; SMN2 (0.40) | THRATHRBSMN1; SMN2PDE5AMEN1 | |
| SCHEMBL4523210 | 0.84 | SMN1; SMN2 (0.40) | THRATHRBSMN1; SMN2PDE5AMEN1 | |
| SCHEMBL4540037 | 0.83 | THRA (0.69) | THRATHRBSMN1; SMN2PDE5AMEN1 | |
| SCHEMBL4354874 | 0.83 | THRA (0.53) | THRATHRBSMN1; SMN2PDE5AMEN1 | |
| SCHEMBL5119983 | 0.83 | SMN1; SMN2 (0.39) | THRATHRBSMN1; SMN2PDE5AMEN1 | |
| SCHEMBL4357825 | 0.82 | THRA (0.40) | THRATHRBSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |