Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 6/20 | 0.39 |
| ▸ | THRA | P10827 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119167 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL5723586 | 0.89 | EPHX2 (0.33) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL5119983 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL4348053 | 0.87 | THRA (0.52) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL4929610 | 0.86 | THRA (0.40) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL4354050 | 0.86 | THRB (0.50) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL5115592 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL5120143 | 0.86 | THRA (0.42) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL4931530 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2THRBTHRAMEN1KMT2A | |
| SCHEMBL4932888 | 0.85 | SMN1; SMN2 (0.39) | SMN1; SMN2THRBTHRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |