Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.37 |
| ▸ | THRB | P10828 | 8/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722595 | 0.90 | THRA (0.45) | THRATHRBKDM4EALDH1A1RCE1 | |
| SCHEMBL5717921 | 0.85 | THRA (0.34) | THRATHRBKMT2APKMKDM4E | |
| SCHEMBL5109270 | 0.83 | HPGD (0.38) | THRATHRBKMT2AKDM4EALDH1A1 | |
| SCHEMBL5717989 | 0.80 | THRA (0.35) | THRATHRBKMT2APKMALDH1A1 | |
| SCHEMBL5717883 | 0.80 | THRA (0.38) | THRATHRBALDH1A1ESR1NR3C1 | |
| SCHEMBL5120105 | 0.79 | THRA (0.59) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5717975 | 0.77 | KMT2A (0.39) | KMT2APKMKDM4EALDH1A1MAPT | |
| SCHEMBL5722524 | 0.77 | THRA (0.40) | THRATHRBKMT2AALDH1A1MAPT | |
| SCHEMBL5717738 | 0.77 | THRA (0.40) | THRATHRBKMT2AMEN1ESR1 | |
| SCHEMBL5717853 | 0.77 | THRA (0.37) | THRATHRBKMT2APKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |