Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 13/20 | 0.45 |
| ▸ | THRB | P10828 | 13/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109270 | 0.90 | HPGD (0.38) | THRATHRBNR3C1PGRKDM4E | |
| SCHEMBL5722600 | 0.90 | THRA (0.37) | THRATHRBNR3C1ESR1PGR | |
| SCHEMBL5120105 | 0.87 | THRA (0.59) | THRATHRBNR3C1ESR1PGR | |
| SCHEMBL5722524 | 0.86 | THRA (0.40) | THRATHRBNR3C1ESR1PGR | |
| SCHEMBL5717913 | 0.85 | THRA (0.42) | THRATHRBNR3C1ESR1PGR | |
| SCHEMBL5717929 | 0.84 | THRB (0.44) | THRATHRBNR3C1ESR1PGR | |
| SCHEMBL5717870 | 0.83 | THRB (0.42) | THRATHRBNR3C1ESR1PGR | |
| SCHEMBL5109714 | 0.82 | SMN1; SMN2 (0.39) | THRATHRBKDM4EALDH1A1CA1 | |
| SCHEMBL5722643 | 0.82 | THRB (0.42) | THRATHRBNR3C1ESR1PGR | |
| SCHEMBL5723368 | 0.81 | THRA (0.43) | THRATHRBNR3C1ESR1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |