SCHEMBL5722657

SCHEMBL5722657

CCCCCCOc1ccc(C2CCc3c(cc(F)c(F)c3O)C2(F)F)cn1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5722700 0.86 NR5A1 (0.40)
SCHEMBL5722639 0.84
SCHEMBL5722631 0.82 CNR2 (0.34)
SCHEMBL5722608 0.80 CYP3A4 (0.33) CYP3A4CYP2D6
SCHEMBL7935212 0.80 NR5A1 (0.40)
SCHEMBL5722695 0.77 CRBN (0.40)
SCHEMBL7931886 0.73 SPHK1 (0.40) CYP3A4
SCHEMBL7922659 0.72 CYP3A4 (0.31) CYP3A4CYP2D6
SCHEMBL5722637 0.72 DRD2 (0.33)
SCHEMBL5722708 0.67 NR5A1 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1028944-B1 FLUORINATED NAPHTHALENE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES AVENTIS RES & TECH GMBH & CO (DE) 2006-01-11 EP disclosed
US-6491989-B1 6,7-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES, 1,1,6,7-TETRAFLUORO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES, 1,6,7-TRIFLUORONAPHTHALENE DERIVATIVES AND 2,3-DIFLUORONAPHTHALENE DERIVATIVES AVENTIS RESEACH & TECHNOLOGIES GMBH & CO. KG (DE) 2002-12-10 US disclosed