Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.41 |
| ▸ | THRB | P10828 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.36 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.36 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5106743 | 0.96 | KMT2A (0.39) | THRATHRBMEN1KMT2ASENP5 | |
| SCHEMBL5115981 | 0.91 | THRA (0.47) | THRATHRBMEN1KMT2ASENP5 | |
| SCHEMBL5722542 | 0.90 | MRGPRX4 (0.37) | THRATHRBMEN1KMT2ASENP5 | |
| SCHEMBL5718126 | 0.90 | MRGPRX4 (0.37) | THRATHRBMRGPRX4ALDH1A1GAA | |
| SCHEMBL5723361 | 0.89 | KMT2A (0.34) | THRATHRBMEN1KMT2ASENP5 | |
| SCHEMBL5722558 | 0.89 | THRA (0.40) | THRATHRBMEN1KMT2ASENP5 | |
| SCHEMBL5722724 | 0.88 | THRA (0.43) | THRATHRBMEN1KMT2ASENP5 | |
| SCHEMBL5718139 | 0.88 | MRGPRX4 (0.38) | THRATHRBMEN1KMT2AMRGPRX4 | |
| SCHEMBL5722490 | 0.88 | THRA (0.43) | THRATHRBMEN1KMT2ASENP5 | |
| SCHEMBL5722494 | 0.87 | THRA (0.42) | THRATHRBMEN1KMT2ASENP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732532-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092316-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF THE THYROID RECEPTOR | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |