Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.56 |
| ▸ | CDK2 | P24941 | 11/20 | 0.56 |
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.46 |
| ▸ | CDK9 | P50750 | 5/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | CCNH | P51946 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723276 | 0.88 | CDK1 (0.57) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723317 | 0.87 | CDK2 (0.59) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723191 | 0.87 | CDK2 (0.55) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723568 | 0.86 | CDK2 (0.51) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723725 | 0.86 | CDK2 (0.50) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL24477749 | 0.86 | CDK2 (0.50) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723688 | 0.85 | CDK2 (0.56) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723476 | 0.85 | CDK2 (0.49) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723609 | 0.85 | CDK2 (0.49) | CDK1CDK2KDRCCNA2CCNT1 | |
| SCHEMBL5723722 | 0.84 | CDK2 (0.48) | CDK1CDK2KDRCCNA2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406876-B1 | 2-ANILINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | EP | disclosed |