Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.48 |
| ▸ | CDK1 | P06493 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.47 |
| ▸ | STK4 | Q13043 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | CCNH | P51946 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723348 | 0.88 | CDK2 (0.61) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723725 | 0.87 | CDK2 (0.50) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723577 | 0.85 | SYK (0.49) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723409 | 0.84 | CDK1 (0.56) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723688 | 0.84 | CDK2 (0.56) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723476 | 0.84 | CDK2 (0.49) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723568 | 0.83 | CDK2 (0.51) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL6223396 | 0.82 | NPC1 (0.55) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723317 | 0.82 | CDK2 (0.59) | CDK2CDK1KDRCCNA2CCNA1 | |
| SCHEMBL5723609 | 0.82 | CDK2 (0.49) | CDK2CDK1KDRCCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406876-B1 | 2-ANILINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | EP | disclosed |