Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 3/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | MGMT | P16455 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5723434 | 0.84 | PIN1 (0.51) | PIN1CSNK1A1CLK4L3MBTL1GAA | |
| SCHEMBL5723482 | 0.81 | PIN1 (0.51) | PIN1CSNK1A1CLK4MAPK1L3MBTL1 | |
| SCHEMBL5723588 | 0.80 | PIN1 (0.56) | PIN1CSNK1A1CLK4MAPK1L3MBTL1 | |
| SCHEMBL3863534 | 0.77 | POLB (0.39) | PIN1POLBMAPK1HSD17B10GAA | |
| SCHEMBL5723859 | 0.76 | PIN1 (0.52) | PIN1CSNK1A1CLK4L3MBTL1GAA | |
| SCHEMBL5723291 | 0.76 | PIN1 (0.52) | PIN1CSNK1A1CLK4CCNA2CDK2 | |
| SCHEMBL5723448 | 0.76 | PIN1 (0.52) | PIN1CSNK1A1CLK4HSD17B10L3MBTL1 | |
| SCHEMBL2527306 | 0.76 | PIN1 (0.59) | PIN1CSNK1A1CLK4L3MBTL1GAA | |
| SCHEMBL20101542 | 0.75 | PIN1 (0.51) | PIN1CSNK1A1CLK4L3MBTL1GAA | |
| SCHEMBL5723403 | 0.74 | PIN1 (0.50) | PIN1CSNK1A1CLK4L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406876-B1 | 2-ANILINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | EP | disclosed |
| US-6939872-B2 | 2-anilino-pyrimidine derivatives as cyclin dependent kinase inhibitors | ASTRAZENECA AB (SE) | 2005-09-06 | — | — | US | disclosed |
| US-20040198757-A1 | 2-anilino-pyrimidine derivatives as cyclin dependent kinase inhibitors | ASTRAZENECA AB (SE) | 2004-10-07 | — | — | US | disclosed |
| EP-1406876-A1 | 2-ANILINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | Astrazeneca AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2002096887-A1 | 2-ANILINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198757-A1 | 2-anilino-pyrimidine derivatives as cyclin dependent kinase inhibitors | CCNT1, CCNI, CDK2 | PIN1 2600/4885CSNK1A1 79/4885CLK4 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.