Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.61 |
| ▸ | TUBB | P07437 | 2/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.61 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.61 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.61 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.61 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.61 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.61 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.61 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.61 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.61 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224074 | 0.89 | ATM (0.61) | KMT2ACYP19A1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL5723843 | 0.88 | ALOX5 (0.66) | CYP3A4CYP1A2TSHRNFKB1LMNA | |
| Water SCHEMBL11279881 | 0.87 | ATM (0.59) | KMT2ACYP19A1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL2221405 | 0.84 | KDM4E (0.59) | KMT2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7410835 | 0.83 | GAA (0.65) | CYP3A4CYP1A2TSHRNFKB1MEN1 | |
| SCHEMBL3126685 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL906528 | 0.83 | ALOX5 (0.67) | CYP3A4CYP1A2TSHRNFKB1LMNA | |
| SCHEMBL5192275 | 0.83 | KDM4E (0.57) | CYP19A1ALOX5PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL5724393 | 0.82 | GAA (0.73) | CYP3A4CYP1A2TSHRNFKB1MEN1 | |
| SCHEMBL28378162 | 0.82 | ALOX5 (0.66) | CYP3A4CYP1A2TSHRLMNATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |